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“Stimulating the Brain with Electricity and Stem Cells”

“Stimulating the Brain with Electricity and Stem Cells”
with Daniel Lim MD PhD
October 21, 2009

Dr. Lim will discuss Neurosurgery for Parkinson’s Disease and other Tremor Disorders, treatments for such disorders ranging from Deep Brain Stimulation (delivery of electrical currents), and the future of stem cell based therapies of such disorders.

Dr. Lim is Assistant Professor in Residence of Neurological Surgery and Director of Restorative Neurosurgery at the UCSF School of Medicine. The focus of his research is on neural stem cells and neurogenesis. He is particularly interested in the molecular biology of the population of neural stem cells found in the subventricular zone (SVZ). For neural stem cells to make neurons, daughter cells need to express certain sets of genes while repressing others. The maintenance of such lineage-specific transcriptional programs is in part regulated by chromatin structure – the “packaged” state of DNA with histone proteins. Recently, Dr. Lim’s work has revealed that the chromatin remodeling factor called Mixed Lineage Leukemia-1 (MLL1) is essential for postnatal neural stem cells to make new neurons. Currently, his work focuses on the molecular mechanisms by which MLL1 specifies a transcriptional program instructive for neurogenesis. In the future he hopes to define the genetic programs and molecular mechanisms that guide the formation of neurons and glia from SVZ neural stem cells, and translate these discoveries into cell-based and genetic therapies for human neurological diseases.
In addition to his basic science interests, Lim has a clinical interest in stereotactic neurosurgery and has worked to study deep brain stimulation for movement disorders including Parkinson’s disease, essential tremor, and atypical tremors resulting from multiple sclerosis or stroke.
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Bad Blood: Interrogating Signaling Networks in Blood Disease

Wed. October 14, 2009
Bad Blood: Interrogating Signaling Networks in Blood Disease
with Michelle Hermiston, M.D. Ph.D.

Dr. Hermiston will talk about her training and experience as a physician and research speacialist in the field of pediatric hematology and oncology. 
 

Dr. Michelle L. Hermiston is a specialist in pediatric cancer and blood diseases at UCSF Children’s Hospital with a special interest in defining the underlying mechanisms in the development of lymphoid malignancies, including leukemia and lymphoma. She earned her medical degree and doctorate in developmental biology at Washington University School of Medicine and the Division of Biology and Biomedical Sciences. Hermiston completed a fellowship in pediatric hematology and oncology and a residency at UCSF before joining the faculty in 2002. She also participated in a Medical Scientist Training Program at Washington University and at the UCSF Molecular Medicine Research Fellowship Program. She holds memberships with numerous organizations, including the American Society of Hematology and American Academy of Pediatrics. Hermiston is an adjunct instructor of pediatric hematology and oncology at the University of California, San Francisco.
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Smashing Protons!

“Smashing Protons!: Exploring Nature’s Fundamental Particles and Forces with the Large Hadron Collider” with Beate Heinemann, Assistant Professor of Physics, UC-Berkeley

(September 30, 2009)

Dr. Heinemann’s experiment recently became famous when it was featured in the blockbuster movie “Angels & Demons” with Tom Hanks. She will discuss particle physics and her work with the Large Hadron Collider in Switzerland.

“The field of “particle physics” tries to understand the physics of the most fundamental building blocks of matter. How many such building blocks are there? How do they relate to each other? Why are they there? Currently we do not have a good theory why we have any mass at all, even though of course we know that all matter has a mass. There are, however, many theories about why this might be and the goal of my experiment is to prove or disprove them, or to maybe find completely unexpected phenomena that will then need to be explained. One exciting possibility is that we find extra dimensions of space that could even result in the production of mini-blackholes. My experiment is called ATLAS and is situated at the “Large Hadron Collider” (abbreviated as LHC) that is located in Switzerland. There are more than 2000 physicists on my experiment, and many engineers and technicians: all of them collaborate with each other to answer some of the most basic and fundamental questions of Science today. In my talk I will describe how this experiment works and what we hope to discover there.”

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Detecting Illicit Nuclear Material with Edward Morse, PhD

Join us for the kick-off to the Marin Science Seminar Fall 2009 season!

Detecting Illicit Nuclear Material with Professor Edward Morse
Wednesday, September 23rd, 2009, 7:30 – 8:30 pm
Terra Linda High School, San Rafael, Room 207

Detecting nuclear material at ports of entry into the United States and at other locations is a daunting problem but is an essential element of a counterterrorism strategy for the country. A major difficulty in detection is the minimization of false-positive signals from a wide variety of cargo containing NORM, or naturally occurring radioactive material. One technique which looks promising is the use of nuclear resonance fluorescence (NRF) for detecting special nuclear material such as U-235. We have embarked on a five year program at UC Berkeley, called DoNuTS (Domestic Nuclear Threat Security), which looks at various aspects of the threat detection problem. This program will be discussed, with emphasis on the physics and technology of NRF as well as other aspects including materials science, computer machine vision, sensor networks, and basic nuclear physics research.

Prof. Edward Morse is a professor of Nuclear Engineering at UC-Berkeley and has a thirty-year involvement in teaching and research at Berkeley in the areas of applied physics, nuclear technology, electronics, and mathematics.

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Aug. 10, 2009 – Field trip to Atlas Cafe “Down to a Science” Science Cafe

From the Down to a Science website. Join us! You can RSVP at the Facebook event page here or by sending me an email at marinscienceseminar@gmail.com.

When: Monday, August 10th 7-9 PM
What: Confessions of an Alien Hunter
Where: Atlas Cafe, 3049 20th St @ Alabama St. in the Mission District
Who: Seth Shostak, Senior Astronomer, SETI Institute, Renowned Alien Hunter
The Deets:
Why do we think aliens are out there? Is Earth really being visited? Will aliens really be short, gray, and hairless? What happens if we pick up a signal from another world?

These are just a few of the questions this month’s guest, Seth Shostak, tackles regularly in his role as the senior astronomer for the SETI (Search for Extra-Terrestrial Intelligence) Institute. Shostak will also discuss the beginnings of life on earth, how this knowledge impacts what astronomers search for in other galaxies, and the growing consortium of scientific voices who believe “it would be offensively self-centered to imagine that what has happened on Earth has only happened on Earth.”

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Before Egg and Sperm: Stem Cells of the Germline


with Diana Laird, Ph.D.

Although we do not need our gametes for 20 or 30 years, they are established during early development in the womb by stem cell precursors. Professor Laird’s research in mouse embryos asks how these cells acquire and maintain their identity, migrate to the forming ovaries or testes, and avoid becoming cancerous on their way to differentiating as egg or sperm.

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NanoHigh: One Session Left

You may have noticed the NanoHigh flyer in the science classroom we have our seminars in. Nanohigh is a series of lectures given by UC Berkeley professors about nanotechnology. The last one, which I attended, discussed the use of carbon. I learned about why there are 2 forms of carbon, the use of nanotubes, the world’s smallest motor, and graphene, the revolutionary material formed when you write with a pencil.

The next talk is about getting things from the lab to the market, and is on April 25, Stanley Hall, 10 AM. Registration is requested, click on the above link for the site

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How we Know What we Know about the Brain


Marin Science Seminar Presentation: “How we Know What we Know about the Brain” (formerly “The Case of the Knocked-Out Neuron: Why brain neurons die and how we can save them”) Dr. Swanson will talk about how we have learned what we know about the brain and about his work’s impact on Alzheimer’s disease and stroke. He will also talk about how scientists work to figure out why neurons die and what can be done to keep them alive.

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