The Science of Designer Babies: a genetic counselor’s perspective

with Liya Rabkina M.S. of Igenomix USA

Wednesday, January 25, 2023 – 7:30 – 8:30pm – Terra Linda High School Innovation Hub, 320 Nova Albion, San Rafael, California

The field of human genetics focuses on managing and preventing inherited disease risks. For families who are at an increased risk for passing on a genetic condition, the preferred option may be preimplantation genetic testing to select for low risk embryos in their future pregnancies. This talk will describe the current state of “designer babies,” what the future of genetic testing for embryos may be, and the ethics of it all. 

An animated model of DNA

Bio: Liya Rabkina is a licensed and board-certified genetic counselor currently working at Igenomix USA in San Francisco. Liya graduated from Terra Linda High School in San Rafael in 2013. She holds a B.A. in Biochemistry from Scripps College and an M.S. in Genetic Counseling from Northwestern University.

Blinded by the Lack of Light

Meredith Protas and student

Genetics of Pigmentation and Eye Loss in the Cave-dwelling Crustacean, Asellus aquaticus

with Meredith Protas, Ph.D. of Dominican University of California, San Rafael

Join us for a Zoom session with Dominican University’s Dr. Meredith Protas. Dr. Protas’s lab investigates the genetics and evolution of cave dwelling animals, specifically crustaceans. The isopod crustacean, Asellus aquaticus, has two different forms: a cave dwelling form and a surface dwelling form. Interestingly, these two forms can be mated together which ultimately allows for an understanding of the genetics behind characteristics found in the cave form such as eye and pigment loss. The questions the lab are asking include:

  • What are the genes and mutations responsible for cave-specific characteristics like eye loss, pigment loss and increased appendage length?
  • In different cave populations are the same or different genes responsible?
  • Where does the variation that causes cave-specific characteristics come from?

To register for this event ask your teacher to contact us, or send a request for registration information via our contact form.

Meredith Protas PhD
Meredith Protas PhD

Before joining the Dominican faculty, Dr. Protas did research at UC Berkeley on cave-dwelling crustaceans and studied the genetic basis of human eye disease in her research work at UCSF. Currently, she uses genetic, molecular, and developmental techniques to answer evolutionary questions about cave animals. Dr. Protas holds a BA in Biology from Pomona College and a PhD in Genetics from Harvard University.

Links:

Photo of Asellus aquaticus, a crustacean
Asellus aquaticus, a crustacean

Interview with Dr. Katie Ferris of UC Berkeley

by Angel Zhou, Branson School

Monkey Flower 

Monkey flowers and mice – two radically different things. Yet, biologists, like Dr. Katie Ferris, are studying how native monkey flowers and mice have adapted to drastically different environments. 
Dr. Ferris currently works with Dr. Michael Nachman at UC Berkeley, using genetic sequencing and samples of monkey flowers and mice to show how organisms are often adapted to their local environment and that these adaptations are genetically based. 
To learn more about Dr. Ferris and her work with Monkey flowers and mice, read the following interview:
1) How did you decide to enter your field of work?
I decided to become a biologist pretty early on in life. When I was little I loved being outside and interacting with the natural world, especially with plants. Because of my attraction to plants I often got in trouble for picking flowers in my mother’s garden. When I was three years old I picked off every single bright green new hosta lily shoot that popped out of the earth. My mother was furious that I had laid waste to her hostas. After she calmed down a little she told me that when I grew up I should be a botanist because then I could pick any plant that I wanted without getting in trouble. The notion stuck and I pursued biology throughout high school and into college. In college I got a job in a lab that studied plant evolutionary genetics and learned a lot of new and exciting things through doing my own research. That experience is how I became interested in my current field of the genetics of adaptation in wild organisms.
2) Describe your typical day at work as a geneticist. What are the best parts of your job? What are the worst parts?
My typical day at work involves several different kinds of activities, which is something I like. Typically I will attend a scientific talk on something related to my interests, do hands-on work with mice (or monkey flowers in my former job), spend an hour or two doing molecular biology in a wet lab and of course spend a little time working on my computer analyzing data or reading scientific papers. The work with animals and in the wet lab usually involved working with undergraduate students who volunteer in the lab in order to participate in research. Some of the best parts of my job are getting to work with students and trying to spread my love of biology and scientific research. I also enjoy the precious and satisfaction of laboratory work and the personalities of the mice. The worst part of my job is when I have to spend a lot of time dissecting dead mice. I did not go into medicine for a reason 🙂
3) How did you decide to study monkey flowers and wild mice specifically? What conclusions have you drawn thus far in your research?
I decided to study monkey flowers when I was interviewing for graduate school. I visited a lot of different labs that studied plants, but the monkey flowers were by far the most captivating. They are bright yellow, happy little things and closely related species live in an incredible range of different environments from old copper mine tailings to salty coastal sand dunes. They are just really cool plants. I became interested in wild mice because of the work my post-doc advisor had done on the genetics of mouse coloration. He found the genetic changes that caused light colored desert mice to become dark when they lived on black rock outcrops. The mice that live on the dark rocks can then blend in to their surroundings and are less likely to be eaten by predators. I like making hypotheses more than drawing conclusions, but I would say that the main conclusion I have drawn from my research so far is that organisms are often adapted to their local environment and that these adaptations are genetically based. I have also concluded that biology is very complicated 
4) What is your ultimate goal in studying the genetics of adaption and speciation?
My ultimate goal in studying the genetics of adaptation and speciation is to understand better how the world around us works. I want to understand which genes are involved in important traits and if the same genes are used repeatedly to evolve the same traits in different organisms. In short, I want to know if the genetic basis of adaptation is predictable in any way. I also just generally want to contribute new knowledge to the scientific community. A better understanding of the genetic basis of ecologically important traits like drought tolerance or coat color can also be used by scientists in applied field to help improve agriculture or medicine. 

Dr. Katie Ferris, UC Berkley
To learn more about the genes and species’ adaptation to extreme environments, join us on Wednesday, April 1st for Dr. Katie Ferris’ seminar, “From Monkey Flowers to Wild Mice: A Tale of Genes, Adaptation and Extreme Environments” in Room 207 at Terra Linda High School in San Rafael. For more information, visit Marin Science Seminar’s Facebook page: https://www.facebook.com/events/850586588342167/

What’s in Our Genes?: How our genes make us who we are”

Wednesday, September 28th, 2011
Terra Linda High School, 320 Nova Albion Way, San Rafael, CA
Room 207

RSVP on FaceBook

with Jane Gitschier, Ph.D. of UCSF’s Institute of Human Genetics

What makes us male or female?  What makes us susceptible to disease?  What makes us different from each other? And what makes us different from other animals?  Come learn the answer to these questions.  It’s all in our genes! Download the flyer. (September 28, 2011)
 

Dr. Gitschier’s laboratory has broad interests in the field of human genetics, ranging from past work on the molecular genetics of hemophilia, through gene discovery for a variety of inherited disorders. Combined with discovery of genes in mouse mutants and the generation of mouse models for human disease, her research has led to a deeper understanding of heavy metal metabolism and has provided more accurate genetic diagnosis and prognosis for families. Currently her lab is engaged in two unusual projects. The first concerns understanding the genetic basis for absolute pitch perception, a rare cognitive trait in which the pitch of a tone or sound can be named without any reference tone. While she hypothesizes that AP has a large genetic component, exposure to music in early childhood is also key. A second project involves the use of DNA haplotypes to infer ancestry, an endeavor known as genetic genealogy.
 
Jane Gitschier joined the UCSF Faculty in 1985 following post-doctoral work at Genentech. She received her PhD from MIT in Biology in 1981. She was an HHMI Investigator and a Guggenheim Fellow. Her longstanding interest is in human genetics. She lives with her daughter Annie Steinberg and cat Pogo in San Francisco.