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“Infectious Disease and the H1N1 Virus”

with Charles Chiu, M.D. Ph.D
Wednesday, January 13, 2010

Research in the Chiu laboratory explores (1) the replication, biology, and pathogenesis of human cardioviruses and (2) detection of known and novel viral agents in acute diseases suspected to have an infectious etiology.
The Chiu lab is actively validating the Virochip and “deep” sequencing for use in clinical diagnostics and in outbreak investigation. Current projects include (1) a prospective longitudinal study of respiratory infections in immunocompromised patients at UCSF, (2) a metagenomics analysis of H1N1 influenza A strains, and (3) design of a respiratory / stool subtyping microarray for use in diagnosis of acute respiratory infections and gastroenteritis.
Dr. Chiu is currently Director of the UCSF Viral Diagnostics and Discovery Center and Assistant Director of the UCSF Microbiology Laboratory.
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How to Bring Solar Energy to Seven Billion People

“How to Bring Solar Energy to Seven Billion People” with Cyrus Wadia, Ph.D.
November 4, 2009


Dr. Wadia is a pioneer in bringing a multidisciplinary approach to solving the complicated issue of renewable energy. Join him in a lively discussion on the promise -and the pitfalls – of solar energy. Download the flyer here.
 

In the city of San Rafael, the only way solar energy can be cost-effective is if the local government provides generous subsidies. That’s true just about everywhere in the world. But what if there were a photovoltaic technology that was so cheap and so easy to install that even the poorest and most remote villages of the world could gain access to electricity? In this presentation, learn about discoveries of new materials that can make solar energy a reality for billions.
By exploiting the powers of nanotechnology and taking advantage of non-toxic, Earth-abundant materials, Cyrus Wadia has fabricated new solar cell devices that have the potential to be several orders of magnitude less expensive than conventional solar cells. And by mastering the chemistry of these materials – and the economics of solar energy – he envisions bringing electricity to the 1.2 billion people now living without it.
Dr. Wadia holds an MS in Chemical Engineering from MIT and a PhD in Energy Resources from UC-Berkeley. He is currently a postdoctoral fellow at the Lawrence Livermore Laboratory in Berkeley. Dr. Wadia spent six years in the high tech industry, has specialized in launching new technologies to market and has completed several successful new product introductions. Presently, Cyrus continues his work helping companies take technology to market as part of an independent consulting practice he began in 2001.

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Making Faces: Developmental Mechanisms of Craniofacial Evolution

“Making Faces: Developmental Mechanisms of Craniofacial Evolution“
with Rich Schneider, Ph.D. 
October 28, 2009


Dr. Schneider will overview experiments in his laboratory that have revealed molecular and cellular processes involved in facial patterning. He will describe how his studies to understand the basis for skull shape in breeds of dogs led him to create a cell transplant system whereby duck embryos develop with quail beaks. He will bring an assortment of skulls.


Dr. Schneider is on the faculty of the Department of Orthopaedic Surgery at UCSF, and in 2004 he was made Director of the Department’s Molecular & Cell Biology Laboratory on the Parnassus Heights campus.

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“Stimulating the Brain with Electricity and Stem Cells”

“Stimulating the Brain with Electricity and Stem Cells”
with Daniel Lim MD PhD
October 21, 2009

Dr. Lim will discuss Neurosurgery for Parkinson’s Disease and other Tremor Disorders, treatments for such disorders ranging from Deep Brain Stimulation (delivery of electrical currents), and the future of stem cell based therapies of such disorders.

Dr. Lim is Assistant Professor in Residence of Neurological Surgery and Director of Restorative Neurosurgery at the UCSF School of Medicine. The focus of his research is on neural stem cells and neurogenesis. He is particularly interested in the molecular biology of the population of neural stem cells found in the subventricular zone (SVZ). For neural stem cells to make neurons, daughter cells need to express certain sets of genes while repressing others. The maintenance of such lineage-specific transcriptional programs is in part regulated by chromatin structure – the “packaged” state of DNA with histone proteins. Recently, Dr. Lim’s work has revealed that the chromatin remodeling factor called Mixed Lineage Leukemia-1 (MLL1) is essential for postnatal neural stem cells to make new neurons. Currently, his work focuses on the molecular mechanisms by which MLL1 specifies a transcriptional program instructive for neurogenesis. In the future he hopes to define the genetic programs and molecular mechanisms that guide the formation of neurons and glia from SVZ neural stem cells, and translate these discoveries into cell-based and genetic therapies for human neurological diseases.
In addition to his basic science interests, Lim has a clinical interest in stereotactic neurosurgery and has worked to study deep brain stimulation for movement disorders including Parkinson’s disease, essential tremor, and atypical tremors resulting from multiple sclerosis or stroke.
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Bad Blood: Interrogating Signaling Networks in Blood Disease

Wed. October 14, 2009
Bad Blood: Interrogating Signaling Networks in Blood Disease
with Michelle Hermiston, M.D. Ph.D.

Dr. Hermiston will talk about her training and experience as a physician and research speacialist in the field of pediatric hematology and oncology. 
 

Dr. Michelle L. Hermiston is a specialist in pediatric cancer and blood diseases at UCSF Children’s Hospital with a special interest in defining the underlying mechanisms in the development of lymphoid malignancies, including leukemia and lymphoma. She earned her medical degree and doctorate in developmental biology at Washington University School of Medicine and the Division of Biology and Biomedical Sciences. Hermiston completed a fellowship in pediatric hematology and oncology and a residency at UCSF before joining the faculty in 2002. She also participated in a Medical Scientist Training Program at Washington University and at the UCSF Molecular Medicine Research Fellowship Program. She holds memberships with numerous organizations, including the American Society of Hematology and American Academy of Pediatrics. Hermiston is an adjunct instructor of pediatric hematology and oncology at the University of California, San Francisco.
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Smashing Protons!

“Smashing Protons!: Exploring Nature’s Fundamental Particles and Forces with the Large Hadron Collider” with Beate Heinemann, Assistant Professor of Physics, UC-Berkeley

(September 30, 2009)

Dr. Heinemann’s experiment recently became famous when it was featured in the blockbuster movie “Angels & Demons” with Tom Hanks. She will discuss particle physics and her work with the Large Hadron Collider in Switzerland.

“The field of “particle physics” tries to understand the physics of the most fundamental building blocks of matter. How many such building blocks are there? How do they relate to each other? Why are they there? Currently we do not have a good theory why we have any mass at all, even though of course we know that all matter has a mass. There are, however, many theories about why this might be and the goal of my experiment is to prove or disprove them, or to maybe find completely unexpected phenomena that will then need to be explained. One exciting possibility is that we find extra dimensions of space that could even result in the production of mini-blackholes. My experiment is called ATLAS and is situated at the “Large Hadron Collider” (abbreviated as LHC) that is located in Switzerland. There are more than 2000 physicists on my experiment, and many engineers and technicians: all of them collaborate with each other to answer some of the most basic and fundamental questions of Science today. In my talk I will describe how this experiment works and what we hope to discover there.”

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Before Egg and Sperm: Stem Cells of the Germline


with Diana Laird, Ph.D.

Although we do not need our gametes for 20 or 30 years, they are established during early development in the womb by stem cell precursors. Professor Laird’s research in mouse embryos asks how these cells acquire and maintain their identity, migrate to the forming ovaries or testes, and avoid becoming cancerous on their way to differentiating as egg or sperm.

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NanoHigh: One Session Left

You may have noticed the NanoHigh flyer in the science classroom we have our seminars in. Nanohigh is a series of lectures given by UC Berkeley professors about nanotechnology. The last one, which I attended, discussed the use of carbon. I learned about why there are 2 forms of carbon, the use of nanotubes, the world’s smallest motor, and graphene, the revolutionary material formed when you write with a pencil.

The next talk is about getting things from the lab to the market, and is on April 25, Stanley Hall, 10 AM. Registration is requested, click on the above link for the site

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